Differential effects of early environmental enrichment on spatial learning and memory of wild house mouse and Kunming mouse / 中华行为医学与脑科学杂志

ABSTRACT

Objective To evaluate and compare the effect of early environmental enrichment on spatial learning and memory in wild house mouse and Kunming mouse,one kind of laboratory mouse which evolved from wild house mouse.Methods The wild house mouse F1 generation were employed to control the environmental enrichment.Offspring were weaned on PND22 and housed in usual or rich environment for one month randomly,then engaged the morris mazehouse moutse rich environment(n=7),house mouse poor environment(n=6),Kunming mouse rich environment(n=10),Kunming mouse poor environment(n=10).Results (1)Early environmental enrichment improve the performance of house mouse(poor environment(39.5±3.8)s;rich environment(25.2±4.5)s;F(1,22)=8.115,P<0.01),but had no effect on that of Kunming mouse in tests of spatial memory (poor environment(8.5±2.4)s;rich environment(7.5±1.7)s;F(1,36)=0.149,P=0.702).(2)Early environmental enrichment improve the performance of house mouse(F(1,132)=15.307,P<0.01)and Kunming mouse (F(1,216)=8.701,P<0.01)in spatial learn session.Conclusion The wild house mouse is more sensitive to the enrich environment than laboratory mouse.Therefore,it has higher validity of model.