Cholangiocarcinoma: risk factor and related pathomechanism / 中华肝胆外科杂志

ABSTRACT

Cholangiocarcinoma is rare. It is highly malignant and early diagnosis is difficult. Various risk facts have been linked to the carcinogenesis and development of cholangiocarcinoma. Chronic inflammation and cholestasis are the two common pathways in the malignant transformation of cholangial cells. We reviewed the molecular biological researches of cholangiocarcinoma from two aspects its risk factors and related pathomechanism.