Genetic analysis of neonatal diabetes mellitus and its influence on treatment outcome / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 488-491, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-416934
ABSTRACT
Fourteen neonatal diabetes mellitus(NDM)patients were recruited. 9 patients were treated with glyburide and the other 5 with insulin. ABCC8, KCNJ11, and INS genes were sequenced in 6 of them. Gene mutations were found in 2, 1, and 1 cases in these genes, respectively. One case with 6q24 hypomethylation and another without known mutation were also found. 8 out of 9 patients treated with glyburide reached euglycemia(88.9%). The other 5 patients with insulin therapy either died or lost contact. The results suggest that glyburide therapy is effective in neonatal diabetes mellitus, while insulin therapy may contribute to poor compliance.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2011
Tipo del documento:
Artículo
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