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A preliminary study of single prolonged stress influence acoustic startle reflex and prepulse inhibition in rats / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science ; (12): 23-25, 2012.
Artículo en Chino | WPRIM | ID: wpr-418187
ABSTRACT
ObjectiveTo explore the deficits of acoustic startle reflex (ASR) and prepulse inhibition (PPI) of acoustic startle reflex in single prolonged stress rats.MethodsSixty Sprague Dawley rats were randomly divided into control 1,7,14 d groups and stress 1,7,14 d groups.All stressed rats received single prolonged stress while all control rats were left in their home cage.Behavioral changes in these rats were analyzed in ASR and PPI paradigm.ASR and PPI were carried out on day 2,8,15,respectively.ResultsThere were no differences of ASR and PPI among control 1,7,14 d groups (P > 0.05).ASR of stress 1 d group ( (92.49 ± 31.54) g) was higher than that of control 1 d group((64.48 ± 17.95)g,P<0.05) while PPI of stress 1 d group((28.60 ±29.02)%) was lower than that of control 1 d group( (41.60 ± 15.10)%,P < 0.05 ).There were no differences of ASR between control 7 d group and stress 7 d group,control 14 d group and stress 14 d group (P> 0.05 ).Compared with control 7 d group ( (41.30 ± 12.79) % ),PPI in stress 7 d group ( ( 17.95 ± 31.79) % ) was reduced (P < 0.05 ).Compared with control 14 d group ( (41.16 ± 12.25 ) % ),PPI in stress 14 d group( ( 13.71 ± 32.48) % ) was reduced (P < 0.05).ConclusionEffects of stress on ASR in rats increased in early period,while the impaired PPI may last for a long time.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Behavioral Medicine and Brain Science Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Behavioral Medicine and Brain Science Año: 2012 Tipo del documento: Artículo