Experimental study of contrast-enhanced ultrasonography on microwave ablation for brain tissue / 中华超声影像学杂志

ABSTRACT

Objective To explore the value of contrast-enhanced ultrasound (CEUS) in microwave ablation for brain tissues,and to provide experimental evidences for clinical application.Methods A total of 17 domestic dog brains underwent microwave ablation randomly at different output power and ablation duration.Ablation lesions were detected by conventional ultrasonography(US) and CEUS in half an hour after MA,the boundary and size of lesions were observed,then the morphology and parameters of timeintensity curve were compared among ablation area,edema area and normal area.Five hours after ablation,brain tissues were took out,morphology and microscope structure changes were observed.Results ① Thirty-four lesions were obtained after microwave ablation.By contrast with US,the size measured by CEUS was smaller,the difference was statistical( P =0.000).The size measured by CEUS proved to be accurate in the results of microscope pathology,and the brain lesions were necrosis completely in no enhancement area.②The parameters of time-intensity curve between edema zone and normal brain had no statistical difference( P =O.992,0.993,0.749),respectively.Conclusions The boundary of necrotic lesions was showed accurately in CEUS,meanwhile the perfusion of ablation zone and surrounding brain could be displayed clearly.CEUS could be used to assess the effect of microwave ablation.