Malignant Lymphoma Associated with Hashimoto's Thyroiditis

ABSTRACT

Primary lymphoma of the thyroid gland is relatively rare disease. Its incidence varies in different series from 1% to 5% of all thyroid malignancies. Most primary thyroid lymphoma are of non-Hodgkin's type, have a B-cell phenotype, and arise in a background of autoimmune thyroiditis in about 80% of cases. A 69-year old woman presented with anterior neck swelling. Ultrasonography and computed tomography demonstrated a heterogenous soft tissue mass in both thyroid lobes and lymphadenopathy. Total thyroidectomy with lymph node dissection was performed. Histopathological findings demonstrated high-grade mucosa-associated lymphoid tissue (MALT)-type lymphoma with Hashimoto's thyroiditis. Radiation therapy was performed. We report a case of primary thyroid lymphoma with Hashimoto's thyroiditis.