Study on relationship between chlamydia pneumonia infection and blood-lipoids,high sensitivity C-reactive protein in ischemic stroke / 中国医师进修杂志

ABSTRACT

ObjectiveTo explore the relationship between chlamydia pneumonia (CPn) infection and blood-lipoids,high sensitivity C-reactive protein (hs-CRP) in ischemic stroke (IS).Methods Ninetyfive patients with IS were selected as study group and 50 healthy people as control group.Serum CPn specific antibody IgG was measured in control group and study group by enzyme-linked immunosorbentassay (ELISA).The levels of serum hs-CRP and blood-lipoids were measured in two groups by automatic biochemical analyzer.The relationship of CPn infection and the levels of serum hs-CRP and blood-lipoids were analyzed.ResultsThe positive rate of CPn IgG and the levels of serum total cholesterol (TC),triglyeride (TG),low density lipoprotein-cholesterol (LDL-C) and hs-CRP in study group [ 58.95％(56/95 ),(5.61 ±0.78) mmol/L,(1.96 ±0.69) mmol/L,(4.19 ±0.58) mmol/L and(10.82 ±2.73) mg/L] were significantly higher than those in control group [ 16.00％ (8/50),(4.15 ± 0.75 ) mmol/L,( 1.10 ± 0.37)mmol/L,(2.26 ±0.46) mmol/L and(4.58 ± 1.06) mg/L] (P ＜0.05),and the level of serum highdensity lipoprotein-cholesterol ( HDL-C ) in study group was lower than that in control group [ ( 1.09 ± 0.34) mmol/L vs. ( 1.32 ± 0.36)mmol/L,P ＜ 0.05 ].In IS patients,the levels of serum TC,TG,LDL-C and hs-CRP in CPn IgG positive patients [ (6.49 ± 0.96),(2.59 ± 0.52),(5.16 ± 0.74) mmol/L and ( 19.25 ± 5.68) mg/L] were significantly higher than those in CPn IgG negative patients [ (4.95 ± 0.59),(1.63 ± 0.43),(3.19 ± 0.71 )mmol/L and(8.29 ± 2.63 ) mg/L] (P ＜ 0.05 ),the level of serum HDL-C in CPn IgG positive patients was significantly lower than that in CPn IgG negative patients [ (0.85 ± 0.21 ) mmol/L vs.( 1.27 ± 0.38) mmol/L,P ＜ 0.05 ].ConclusionsThere is significant correlation between CPn infection and IS.CPn infection may be involved in the pathogenesis of IS by increasing the expression of blood-lipoids and hs-CRP.