Association between gene polymorphism of plasminogen activator inhibitor and ischemic cerebrovascular disease in aged people of Henan Han nationality / 中华老年医学杂志
Chinese Journal of Geriatrics
; (12): 994-997, 2012.
Article
en Zh
| WPRIM
| ID: wpr-420766
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WPRO
ABSTRACT
Objective To investigate the association between gene polymorphism of plasminogen activator inhibitor (PAI-1)and ischemic cerebrovascular disease in aged people of Henan Han nationality.Methods A case control method was used,including 408 patients with ischemic cerebrovascular disease and 418 age and gender matched healthy controls.Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method was used to determine the distribution of allele and genotype frequencies of PAI-1 844G/A.Results In patient group,the gene frequencies of AA,AG,GG were 18.1%,41.4%,40.4%,and the A and G allele frequencies were 38.8% and 61.2%,respectively.In the control group,the gene frequencies of AA,AG,GG were 15.8%,47.4%,36.8%,and the A and G allele frequencies were 39.5% and 60.5%.There were no significant differences in the frequencies of genotypes and alleles between the two groups (P>0.05).The different genotypes of 844G/A of PAI-1 gene were not associated with hypertension,hyperglycemia,plasma homocysteic acid levels (P > 0.05).Conclusions PAI-1 gene-844G/A polymorphism may not be independent risk factor of ischemic cerebrovascular disease in aged people of Henan Han nationality.
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Índice:
WPRIM
Tipo de estudio:
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of Geriatrics
Año:
2012
Tipo del documento:
Article