A Case of Hand-Schuller-Christian Disease with Exophthalmos

ABSTRACT

Hand-Schuller-Christian disease, eosinophilic granuloma and Letterer-Siwe disease are classified as histiocytosis-x, on the basis of the underlying proliferation of histiocytes in all three conditions and of their indefinite etiology. The authors experienced a case of Hand-Schuller-Christian disease with exophthalmos. A 17 months old boy was admitted to our Dept. of Ophthalmology because of left exophthalmos since 2 months ago. A biopsy demonstrated that the lesion was Hand-Schuller-Christian disease. The patient was treated with chemotherapy and low dose radiation therapy. We report our experience with this patient along with the review of other papers in this report.