Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
;
: 223-228, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-42179
ABSTRACT
6-Gingerol exerts anti-tumor effects in various cancer cell models. We evaluated the effect of 6-gingerol on the growth of MCF-7 breast cancer cells and MCF-10A breast epithelial cells to determine whether any growth-inhibitory effects found were attributable to apoptosis, and to elucidate the underlying mechanism of action. 6-Gingerol inhibited the viability of both cell lines in a dose- and time-dependent manner; however, the degree of inhibition was greater in MCF-7 than MCF-10A cells. By flow cytometry, induction of dose- and time-dependent apoptosis was found, and the magnitude of apoptosis was also markedly greater in MCF-7 than MCF-10A cells. Expression of caspase-3 and poly (ADP-ribose) polymerase (PARP) was observed in MCF-7 cells treated with 6-gingerol, and further cleavage of PARP occurred in these cells. We suggest that 6-gingerol induces apoptosis in human breast cancer cells mainly by promoting caspase-3 expression and subsequent degradation of PARP.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mama
/
Neoplasias de la Mama
/
Línea Celular
/
Apoptosis
/
Células Epiteliales
/
Caspasa 3
/
Células MCF-7
/
Citometría de Flujo
Límite:
Humanos
Idioma:
Inglés
Revista:
International Journal of Oral Biology
Año:
2015
Tipo del documento:
Artículo
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