Antioxidafion functions of Guizhi-Fuling Capsule in rats with atherosclerosis / 国际中医中药杂志

ABSTRACT

Objective To study antioxidation functions effect of Guizhi-Fuling Capsule in rats with atherosclerosis(AS). Methods 50 healthy SD male rats were randomly divided into 2 groups normal group(n=12), and AS model group (n=36). The model of experimental AS rats was established by high cholesterol diet and intraperitoneal injecting Vit D3. The normal control group was fed by ordinary diet. AS model group was randomly divided into 3 groups AS group (n= 12), control group (n= 12), therapy group (n=12). Therapy group was given Guizhi-Fuling Capsule (0.24 g/kg · d-1) , control group was given simvastafin (0.86 mg/kg · d-1 ) and captopril(4.3 mg/kg · d-1)by intragastric administration for four weeks. Oxidized-low density lipoprotein (oxLDL),malondialdehyde (MDA), superoxide dismutase(SOD) in serum were detected at the end of therapy. Results Compared with the normal group The oxLDL [ (83.46 ± 19.42)pg/dl], MDA [ (7.38 ±2.46)nmol/ml] in serum were increased significantly(both P＜0.01 ), while SOD[ (135.70±23.49)nu/ml] was decreased significantly (P＜0.01 )in AS model group. Compared with the model group, the oxLDL[(45.87± 1l.91)pg/di], MDA[ (5.27 ±1.95)nmol/ml] in serum in control group ,the oxLDL[(26.73±9.06)pg/dl], MDA[(4.05±1.83)nmol/ml] in serum in therapy group were lower significandy (all P＜0.01 ), and the lowering effect in therapy group was better than that in control group. SOD in serum was higher significantly in the two treatment groups [in control group (185.87±37.36)nu/ml (P＜0.01)、 in therapy group (158.65±31.4S) nu/ml (P＜0.05) ], and the increasing effect in therapy group was better than that in control group. ConclusionGuizhi-Fuling Capsule has the effects of resisting atherosclerosis to rats with AS. Its mechanisms maybe relate to its antioxidation functions.