The Human Microbiome Project: Beginning and Future Status / 대한임상미생물학회지

ABSTRACT

In 1884 Robert Koch and Friedrich Loeffler published Koch's Postulates defining our historical understanding of the relationship between an organism and infection one organism one disease. In the last decade with research on the microbial community living on and in humans, a new concept of microbial diseases has emerged; that is, alterations of the microbial community can lead to disease including an extension beyond traditional "infectious" diseases to include metabolic disorders such as type 2 diabetes and obesity. As we continue to gain knowledge about the functions of the normal microbiome and the effects of alterations of the microbial population on disease pathogenesis, a new era of diagnostics and therapeutics will evolve.