Clinical operational threshold of neonatal hypoglycemia / 中国小儿急救医学

ABSTRACT

ObjectiveTo search clinical operational threshold of neonatal hypoglycemia.Methods From Jan 2007 to Jan 2009,128 neonates in our hospital were divided into 4 groupsnormal control group (blood glucose range 3.30 ～ 6.10 mmol/L during hospitalization) ;treatment I group (blood glucose range 2.60 ～ 3.29 mmol/L keep 2 h,maintain normal range after 4 h) ; treatment Ⅱ group ( blood glucose range 2.20 ～ 2.59 mmol/L keep 2 h,maintain normal range after 4 h ) ;treatment Ⅲ group(blood glucose ＜2.20 mmol/L keep 2 h,maintain normal range after 3 h).Relevant data of the latency of main waves on the neonates were collected and analyzed by flash visual evoked potential( F-VEP) test.ResultsThe main waves of F-VEP in all the 128 neonates were existed.The latency of main waves in group Ⅱ [ (212.9 ± 18.9) ms] and group Ⅲ [ (223.1 ±20.4) ms] were significantly longer than that in the normal control group [ ( 199.2 ± 14.3) ms] respectively (P ＜0.01 ),and the latency of main wavesin group Ⅲ were longer than that in group Ⅱ ( P ＜0.01 ).There were no significant difference in group I [ (203.3 ± 15.4) ms ] as compared with the other groups (P ＞ 0.05 ).When blood glucose of the treatment group maintain on 3.30 ～ 6.10 mmol/L,the latency of main waves of F-VEP in group Ⅱ and group Ⅲ [ (202.9 ± 15.2) ms,(203.1 ± 15.5) ms ] had no differences as compared with the control group[ ( 199.2 ± 14.3 ) ms ] (P ＞ 0.05 ).ConclusionIt may be appropriate that the threshold of blood glucose for diagnostic criteria of neonatal hypoglycemia is less than 2.60 mmol/L rather than 2.20 mmol/L,whether the neonates have any clinical manifestations or not.