Drug-induced liver injury,drug disposition and metabolite profiling / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 467-475, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-424068
ABSTRACT
Drug-induced liver injury (DILI) is a leading cause responsible for the failure of drug development and for the withdrawal of commercial drug products.The high frequency of DILI is due in part to the physiology of the liver,since in many cases elimination of drug molecules from the body is dependent on hepatic clearance via either metabolism or biliary excretion.Many of the mechanistic details underlying DILI remain poorly defined in spite of extensive studies of the pathogenesis.In this regard,metabolomics may become a powerful tool for investigation of DILI,leading to better mechanistic understanding and biomarkers identification.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2012
Tipo del documento:
Artículo
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