Correlation study on angiotensin Ⅱ type 2 receptor gene single nucleotide polymorphisms in essential and renal hypertension / 中国综合临床
Clinical Medicine of China
;
(12): 351-353, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-425304
ABSTRACT
Objective To study the relationship between angiotensin Ⅱ type 2 receptor (AGTR2) gene single nucleotide polymorphisms and hypertension in patients with essential hypertension and renal hypertension.Methods Direct DNA sequencing was performed to detect the single nucleotide polymorphisms (SNP) in eighty patients with essential hypertension,eighty patients with renal hypertension and forty normal blood pressure controls.Results There was significant difference on A allele frequencies between essential hypertension group and control group ( 56.88% [ 91/160 ] vs 30.00% [ 24/80 ],x2 =15.44,P < 0.001 ).A allele frequency had no correlation with renal hypertension (42.50% [ 68/160 ] vs 30.00% [ 24/80 ],x2 =3.52,P >0.05).There was no significant difference on SNP between essential hypertension group and renal hypertension group ( P > 0.05 ).Conclusion A1675G signal nucleotide polymorphisms of AGTR2 may be associated with the development of essential hypertension,but has nothing to do with renal hypertension.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Clinical Medicine of China
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS