Clinical effects and safety of salmeterol combined with fluticasone propionate dry powder in the treatment of cough variant asthma / 中国基层医药

ABSTRACT

ObjectiveTo investigate the effect and safety of salmeterol combined with fluticasone propionate dry powder in the treatment of cough variant asthma(CVA).Methods45 children diagnosed as CVA(aged from 5 to 14 years old)were randomly divided into treatment group(n =23)and control group(n =22).The patients in treatment group were treated with salmeterol combined with fluticasone propionate every morning and evening,while the control group were only given fluticasone propionate every morning and evening.The two groups were treated for 3 months.The change of clinical symptoms,asthma control time,lung function (PEF％ pred) and adverse reactions were observed before and after treatment.ResultsCough was relieved in most cases after treatment in both groups,but the improvement was more significant in treatment group than that in control group 1 week after treatment( x2 =10.24,P ＜ 0.05).However,there were no significant differences of clinical efficacy between two groups 2 weeks later( P ＞0.05).Full control time of asthma was in treatment group,which was significantly earlier than the control group( t =8.36,P ＜ 0.05 ).PEF％ pred was shorter significantly higher in two groups after 1 week,2 and 4 weeks,but the improvement was more significant in treatment group than that in control group( t =6.22,7.68,7.95,all P ＜ 0.05 ).1 case of headache in treatment group was relieved by symptomatic treatment and no other serious adverse events occured.ConclusionSalmeterol combined with fluticasone propionate was safe,effective,easy to use for treating CVA.