Research on the correlation of COX-2 and renal cell carcinoma / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 1460-1461, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-425838
ABSTRACT
ObjectiveTo explore the expression of Cyclooxygenase-2-specific(COX-2) in renal cell carcinoma and its relationship with angiogenesis.MethodsThe expression of COX-2,VEGF and bFGF in renal cell carcinoma specimens(85 cases) and adjacent normal tissue samples(48 cases) was measured by immunohistochemistry.Microvessel density (MVD) was evaluated by immunohistochemistry using a monoclonal antibody against CD34.ResultsThe positive expression rates of COX-2,VEGF and bFGF in adjacent normal tissue were 16.7%,20.8%,22.9%,and 77.6%,80.0%,74.1% in renal cell carcinoma,respectively,the difference,were significant ( all P <0.01 ).MVD was (55.47 + 18.47 ) Counts/field in renal cell carcinoma,and ( 20.42 ± 8.72) Counts/field in adjacent normal tissue,the difference was significant( P < 0.01 ).MVD in renal cell carcinoma which was positive expressed COX-2,VEGF,bFGF was higher than renal cell carcinoma which was negative expressed COX-2,VEGF,bFGF,the difference was significantly statistical( P < 0.05 or P <0.01 ).COX-2 expression and VEGF,bFGF in renal cell carcinoma expression was positively correlated( P <0.01 ).Conclusion COX-2 expression was elevated in renal cell carcinoma,and it was related closely with renal cell carcinoma angiogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Primary Medicine and Pharmacy
Año:
2012
Tipo del documento:
Artículo
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