Progress in the relationship of the endothelial dysfunction and chronic kidney disease / 国际儿科学杂志

ABSTRACT

Most chronic kidney diseases are complicated by tubulointerstitial inflammation and fibrosis,leading to progressive deterioration of renal function,and potentially ultimately resulting in irreversible end-stage kidney.And the advanced tubulointerstitial damage is often associated with the lose of peritubular capillaries.With the close relationship of the lose of peritubular capillaries and the progress of chronic kidney diseases,this review reprents the relationship of endothelium and the progress of chronic kidney diseases through three levels including endothelial injury,repairment,and relative intervention,in order to aid in the recognition,intervention and therapy of chronic kidney diseases.