Effect of vertebral artery origin tortuosity on vascular vertigo and clinical risk factors for the tortuosity / 中华老年医学杂志

ABSTRACT

Objective To investigate the clinical risk factors of vertebral artery origin tortuosity and its impact on vascular vertigo. Methods Totally 206 inpatients in Department of Neurology were divided into tortuous group (n=137) and non-tortuous group (n=69).Clinical risk factors of cerebral vascular disease,vertigo scales and days of treatment relieve were recorded.Total cholesterol (CH),low density lipoprotein cholesterol (LDL-C),homocysteic acid (Hcy) and high sensitivity Creactive protein (hsCRP) were detected.Cervical computer tomography angiography (CTA) and contrast enhancement magnetic resonance angiography (CEMRA) were completed.The risk factors of vertebral artery origin tortuosity were analyzed with multiple logistic regression analysis. Results Vertebral artery dominance was much more in tortuous group than non-tortuous group(x2 =2.496,P＜0.01).Vertigo scales from 1 to 5 appeared in 17 cases,36 cases,79 cases,4 cases,1 case,respectively,and days of treatment relieve were 1-10 d in tortuous group,hut the corresponding data was 18 cases,35 cases,10 cases,3 cases,1 case and 1-6 d in non-tortuous group with statistical significance between the two groups(t=2.014,2.849,P＜0.01).The distinctions were found in age more than 65 years,hypertensive disease,high LDL-C,diabetes mellitus,smoking,stroke history,vertebral artery dominance and cervical spondylosis between tortuous group and non-tortuous group(x2=7.498,5.182,3.724,10.46,6.883,2.748,4.496,8.265,all P＜0.05).Age more than 65 years (95％CI5.36-18.23,OR=4.84),hypertensive disease(95 ％ CI2.79-16.45,OR=3.21),vertebral artery dominance(95％ CI3.25-13.49,OR =5.48) and cervical spondylosis (95％ CI4.38-21.28,OR=3.57) were high clinical risk factors. Conclusions Patients with vertebral artery origin tortuosity present with higher vertigo scales and longer days of treatment relieve.Age more than 65 years,hypertensive disease,vertebral artery dominance and cervical spondylosis are clinical risk factors for vertebral artery origin tortuosity.