Exploring the Validity of Valproic Acid Animal Model of Autism
Experimental Neurobiology
;
: 285-300, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-42754
ABSTRACT
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the structural and behavioral features that can be observed in individuals with autism. These similarities enable the model to define relevant pathways of developmental dysregulation resulting from environmental manipulation. The uncovering of these complex pathways resulted to the growing pool of potential therapeutic candidates addressing the core symptoms of ASD. Here, we summarize the validity points of VPA that may or may not qualify it as a valid animal model of ASD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastorno Autístico
/
Ácido Valproico
/
Modelos Animales
/
Trastorno del Espectro Autista
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2015
Tipo del documento:
Artículo
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