The influence of edaravone on serum IL-6、 TNF-α、 ET、 sICAM-1 and MCP-1 in acute intracerebral hemorrhage patients / 中国基层医药

ABSTRACT

Objective To study the influence of edaravone on serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in acute cerebral hemorrhage patients,discuss the protective mechanism of edaravone on cerebral hemorrhage.Methods 100 patients with acute cerebral hemorrhage were randomly divided into treatment group and control group (50 cases),the serum levels of IL-6,TNF-α,ET,sICAM-1 and MCP-1 were detcted by ELSA at pretherapy and after given treatment.Neurological functional deficit scores were utilized for assessment at pretherapy and after given treatment.A healthy control group which approximately matched the experimental group included 30 persons.Results The levels of serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in both two groups after treatment were significantly lower than those before treatment( all P ＜ 0.05 ),and the levels of serum IL-6,TNF-α,ET,sICAM-1 and MCP-1 in edaravone therapy group significantly lower those that in conventional therapy group( P ＜0.05 ).NDS of both groups after treatment were lower than those before treatment (P ＜ 0.05 ),and the scores of edaravone therapy group were significantly lower than those of conventional therapy group( P ＜ 0.05 ).Conclusion Edaravone can decrease the levels of IL-6,TNF-α,ET,sICAM-1 and MCP-1 in patients with acute cerebral hemorrhage.It could lighten acute inflammation and brain injured,lessen nerve function impairment,and protect the tissue of brain.