Molecular characteristics of the hemagglutinin and neuraminidase of influenza B viruses isolated in Jiangsu province, 2011 / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 1026-1033, 2012.
Article
en Zh
| WPRIM
| ID: wpr-429356
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ABSTRACT
Objective To characterize the molecular characteristics of hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses isolated in Jiangsu province,2011.Methods Thirteen strains of influenza B virus in different areas and epidemic period in Jiangsu province,2011 were selected for whole-genome sequencing,and analysis of molecule epidemic characteristics for HA and NA was carried out by bioinformatics method.Results Of the 13 randomly selected influeuza B strains,10 strains were assorted to Victoria lineage strains with NA genes from Yamagata lineage,and 3 strains belong to Yamagata lineage.Compared nucleotide and amino acid sequences of HA and NA genes with their vaccine strains respectiuely,196/197 glycosylation site appeared on HA1 gene in Yamagata/Victoria isolates virus.Conclusion Both B/Victoria and B/Yamagata lineage viruses co-circulated in Jiangsu province,and reassortant virus of Victoria lineage were predominant virus.
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Chinese Journal of Microbiology and Immunology
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2012
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Article