Correlation analysis of B cell activating factor promotor polymorphism-871 C/T and systemic lupus erythematosus / 中华风湿病学杂志
Chinese Journal of Rheumatology
;
(12): 124-126, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-429484
ABSTRACT
Objective The study was aimed to detect the correlation of B cell activating factor (BAFF) promotor polymorphism-871 C/T and systemic lupus erythematosus (SLE).Methods BAFF promotor polymorphism-871 C/T was detected by the means of allele specific polymerase chain reaction (ASPCR) and agarose gel electrophoresis in 76 cases of SLE and 80 nonthrombosis normal individuals.The data of genotypic frequency and allele genotypic frequency were analyzed statistically with x2 test between the two groups.Results Fifty-one point two percent of normal individuals exhibited C/C.Thirty-five percent were heterozygous for C/T,and 13.8% were homozygous for T/T.SLE group exhibited a different distribution pattern (30.3% C/C,43.4%C/T,26.3%T/T).The allele frequency of T in SLE and normal individuals was 48.0% and 31.2% respectively.There was significant difference in the BAFF-871 C/T genotypic frequency between the SLE and nonthrombosis normal individuals (P<0.05).Conclusion The polymorphism-871 C/T of BAFF promoter is correlated with the pathogenesis of SLE.The gene may be a major susceptible gene for SLE in Chinses Han people.Further investigations may be needed.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Rheumatology
Año:
2013
Tipo del documento:
Artículo
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