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Case-control study on the serum sex steroids levels in prepuberal children with autism / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science ; (12): 991-993, 2012.
Artículo en Chino | WPRIM | ID: wpr-429969
ABSTRACT
Objective To investigate the changes of the serum sex steroids levels in prepuberal children with autism,and analyze the possible clinical implications.Methods The serum sex steroids,including folliclestimulating hormone(FSH),luteotropic hormone(LH),testosterone(T),estradiol(E2),progesterone(P),dehydroepiandrosterone sulfate(DHEA-S) and androstenedione were measured in 44 autistic children(35 boys and 9girls,47.5 ± 18.9 months) and 44 normal children(35 boys and 9 girls,45.0 ± 18.7 months),using chemiluminescence immunoassay.Results ①The progesterone levels in autism group were significantly lower than control group((< 0.48,2.08) nmoL/L vs (< 0.48,6.95) nmol/L,Z =-3.564,P < 0.01),but no statistical differences were observed in other sex steroids levels(P> 0.05).②The progesterone levels in < 48 months autism group showed no significant differences from ≥48 months autism group (Z =0.150,P > 0.05).There were no statistical differences in progesterone level between the boys and girls of the autism group(Z=1.972,P>0.05).Conclusion The progesterone levels are lower in autistic children,and they are not associated with the children's age or gender.This study indicates that the progesterone levels are closely associated with autism.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio observacional / Factores de riesgo Idioma: Chino Revista: Chinese Journal of Behavioral Medicine and Brain Science Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio observacional / Factores de riesgo Idioma: Chino Revista: Chinese Journal of Behavioral Medicine and Brain Science Año: 2012 Tipo del documento: Artículo