Basic research of the interaction between chemotherapy agent and magnesium isoglycyrrhizinate / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 944-947, 2012.
Article
en Zh
| WPRIM
| ID: wpr-430156
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WPRO
ABSTRACT
Objective Under the circumstance of continuous arterial infusion,role of magnesium isoglycyrrhizinate combined with different kinds of chemotherapy agents respectively were detected on the HepG-2 and 7702cell lines.Method MTT assay in cultured HepG-2 and 7702 in vitro were used to detect different chemotherapy agents combined with transemetil with different sequence; interaction of MgSO4 with chemotherapy agents were observed in HepG-2 cell lines.Results When combined with docetaxel,gemcitabine,epirubicin,5 fluorouracil,pemetrexed disodium,magnesium isoglycyrrhizinate had synergistic effect; when combined with other agents,there were no antagonism effect; 4 kinds of chemotherapy agents had slight synergistic effect with magnesium sulfate.Conclusion Magnesium isoglycyrrhizinate showed obvious synergistic effect when combined with chemotherapy agents; different sequence between magnesium isoglycyrrhizinate and chemotherapy agents showed different effect; the mechanism need more study.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Hepatobiliary Surgery
Año:
2012
Tipo del documento:
Article