FcγR gene polymorphisms in Kawasaki disease susceptibility and the efficacy of intravenous immunoglobulin therapy / 国际儿科学杂志

ABSTRACT

Fcgamma receptors family conclude three groups(CD64、CD32、CD16),of which FcγR Ⅱa,Ⅱb,Ⅲb have Gene polymorphisms,for this reason they have an effect on affinity of FcγR to antibodies different,so FcγRⅡa,Ⅱb,Ⅲb are related to genetic susceptibility and IVIG treatment response.The Gene subtype of FcγR Ⅱ a is considered to be the susceptibility genes of KD.Polymorphisms of FcγRs were intimately connected to pathogenesis,coronary artery impairment and disease prevention of Kawasaki disease.