Vitamin D status and its effect on bone mineral density of the middle and old aged women in the urban area of Guiyang / 中华内分泌代谢杂志

ABSTRACT

Objective To evaluate vitamin D status of the middle and old aged women in the urban area of Guiyang,and to explore the impact of vitamin D status on the bone mineral density.Methods A total of 511 healthy women,aged 40 to 79 years old,living in one of the urban communities in Guiyang,were selected by means of stratified cluster sampling.The levels of serum 25-hydroxyvitamin D [25 (OH) D] and intact parathyroid hormone (iPTH) were detected by radioimmunoassay.In addition,the bone mineral density (BMD) of hip,lumbar vertebrae 1-4 (L1-4),and neck of left femur were detected by Dual energy X ray absorptiometry.Results The average serum level of 25(OH)D in all subjects was (21.3 ± 7.9) ng/ml and that of iPFH was (29.3 ± 16.5) pg/ml.Severe deficiency [25 (OH) D＜ 10 ng/ml],deficiency [10 ≤ 25 (OH) D＜20 ng/ml],insufficiency [20 ≤ 25 (OH) D ≤ 30ng/ml],and sufficiency [25 (OH) D＞ 30 ng/ml] of vitamin D were ascertained in 5.3％,42.3％,37.9％,and 14.5％ of the total cases respectively.The morbidity of secondary hyperparathyroidism was 4.7％.The level of 25 (OH) D was positively correlated with the BMD of L1-4 and neck of left femur (both P＜0.01).The level of iPTH was negatively correlated with BMD of neck of left femur and L1-4 (both P＜0.05).Conclusion The majority of middle and old aged women in the urban area of Guiyang city were found to be of vitamin D deficiency and insufficiency.Vitamin D status is positively correlated with BMD at lumbar spine and proximal femur.Serum 25 (OH) level below 20 ng/ml is associated with raised parathyroid hormone,which increases the risk of osteoporosis.