Typing of amyloidosis in renal biopsies of 205 cases / 中华肾脏病杂志
Chinese Journal of Nephrology
;
(12): 88-92, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-431278
ABSTRACT
Objective To identify the prevalence of different amyloid types in renal biopsies.Methods The renal biopsies of 205 patients diagnosed as renal amyloidosis from January 1990 to December 2011 were reassessed.Immunohistochemistry was performed with a penal of antibodies directed against λ-light chain,κ-light chain,amyloid A,fibrinogen,transthyretin,apolipoprotein A1,and lysozyme.Immune electron microscopy and gene analysis were performed when the results of immunohistochemistry were indeterminate.Results Among 205 patients,190 cases (92.7%) were classified as immunoglobulin light chain amyloidosis (AL),1 (0.5%) case as amyloid A amyloidosis and 1 (0.5%) case as fibrinogen A α-chain amyloidosis.The amyloid types of remaining 13 (6.3%) cases were undetermined.In the AL patients,the distribution of λ and κ was 6.6∶1.Conclusion AL is the most common form of renal amyloidosis in China,with a predominant light chain type of λ.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Nephrology
Año:
2013
Tipo del documento:
Artículo
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