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Synthesis and analgesic activities of phenyl piperazinyl aralkyl ketone derivatives / 药学学报
Acta Pharmaceutica Sinica ; (12): 1511-6, 2012.
Artículo en Chino | WPRIM | ID: wpr-433006
ABSTRACT
To explore novel non-opioid analgesic agents, 16 compounds were synthesized and their structures were confirmed by 1H NMR and HR-MS. YX0611-1 was treated as the leading compound. The results of mice writhing model and hot plate model showed that compounds 2, 7, 8, 9, 11 and 15 had obvious analgesic activities in vivo. The test of affinity to mu, delta, kappa receptor displayed that active compounds didn't act on opioid receptor. The results of preliminary toxicity and pharmacokinetic tests showed that compound 7 had better safety and pharmacokinetic properties than that of YX0611-1, and it deserved further development.
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2012 Tipo del documento: Artículo