Effect of Xilei Powder on primary cultured fibroblast functions related to wound healing / 中成药
Chinese Traditional Patent Medicine
;
(12): 30-35, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-433197
ABSTRACT
AIM:
Xilei Powder,a traditional Chinese prescription,has been used to treat wounds for hundreds of years,but the mechanism has not been fully understood.METHODS:
The effects of Xilei Powder on fibroblast proliferation,collagen accumulation,matrix metalloproteinases-2,9 ( MMP-2,9 ) activities and tissue inhibitor of metalloproteinase 1 (TIMP-1) production were investigated by MTT,chloramine T method,gelatin zymography and enzyme-linked immunosorbent assays ( ELISA),respectively.RESULTS:
The aqueous extract of Xilei Powder significantly promoted fibroblasts proliferation in a time and concentration manner,the population doubling time (125 μg/mL) was 33.8 h,it also significantly (P <0.05 ) promoted collagen production.Both of the aqueous and alcoholic extracts could significantly ( P < 0.05 ) increase MMPo2 activity,and also very significantly ( P < 0.01 )promote TIMP-1 production.CONCLUSION:
Xilei Powder could promote fibroblasts proliferation,collagen and TIMP-1 production,this might be parts of mechanism to promote wound healing.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional Patent Medicine
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS