Your browser doesn't support javascript.
loading
Effect of Xilei Powder on primary cultured fibroblast functions related to wound healing / 中成药
Chinese Traditional Patent Medicine ; (12): 30-35, 2010.
Artículo en Chino | WPRIM | ID: wpr-433197
ABSTRACT

AIM:

Xilei Powder,a traditional Chinese prescription,has been used to treat wounds for hundreds of years,but the mechanism has not been fully understood.

METHODS:

The effects of Xilei Powder on fibroblast proliferation,collagen accumulation,matrix metalloproteinases-2,9 ( MMP-2,9 ) activities and tissue inhibitor of metalloproteinase 1 (TIMP-1) production were investigated by MTT,chloramine T method,gelatin zymography and enzyme-linked immunosorbent assays ( ELISA),respectively.

RESULTS:

The aqueous extract of Xilei Powder significantly promoted fibroblasts proliferation in a time and concentration manner,the population doubling time (125 μg/mL) was 33.8 h,it also significantly (P <0.05 ) promoted collagen production.Both of the aqueous and alcoholic extracts could significantly ( P < 0.05 ) increase MMPo2 activity,and also very significantly ( P < 0.01 )promote TIMP-1 production.

CONCLUSION:

Xilei Powder could promote fibroblasts proliferation,collagen and TIMP-1 production,this might be parts of mechanism to promote wound healing.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Traditional Patent Medicine Año: 2010 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Traditional Patent Medicine Año: 2010 Tipo del documento: Artículo