PRELIMINARY STUDIES OF ALBENDAZOLE (ABZ),ALBENDAZOLE-SULFOXIDE (ABZSX) AND AIBENDAZOLE-SULFONE(ABZSN) ON THE ENZYME COMPLEXES ACTIVITIES IN MITOCHONDRIA OF ASCARIS SUUM MUSCLE / 中国人兽共患病学报
Chinese Journal of Zoonoses
;
(12): 74-75, 2000.
Artículo
en Chino
| WPRIM
| ID: wpr-433745
ABSTRACT
AimTo study the mechanism of ABZ,ABZSX and ABZSN on Ascaris Suum. MethodsThe activities of enzyme complexes in mitochondria were detected by spectrophotometer for the study of effects of ABZ, ABZSX and ABZSN on the anaerobic respiratory chain of enzyme complexes in mitochondria of Ascaris Suum muscle and rat liver. ResultsThe activity of succinate CoQ reductase in Ascaris muscle mitochondria was apparently suppressed by ABZ ,ABZSX. Conclusion Preliminary study on the mechanism and toxicity of ABZ through enzyme studies,in order to find a more effective and satisfactory drug with low toxicity for clinical use.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Zoonoses
Año:
2000
Tipo del documento:
Artículo
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