Inhibitory effects of domestic incadronate on osteoclastic bone resorption in vitro / 安徽医科大学学报

ABSTRACT

Objective　To study the effects of domestic incadronate(ICD) on osteoclastic bone resorbing lacunae. Methods　Rabbit's osteoclastes were coincubated with bone slices and microphotographed,microdensitometric scanned and analyzed by computer image analysis system. Results　ICD (0.5，5 and 50 μmol/L) caused dose-dependent reduction in the number of osteoclastic bone resorbing lacunae. The inhibitory effect ICD (5 μmol/L) was more remarkable than that of aminopropanediphosphonate (APD). Both ICD and APD reduced the surface area of osteoclastic bone resorbing lacunae. The effect of ICD was stronger than that of APD. Conclusion　ICD directly suppresses osteoclastic bone resorption and may be effective in osteoporosis.