Study on the Anti-inflammatory Effect of Biota orientalis / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 224-226, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-433951
ABSTRACT
AIM The purpose is to investigate the Anti-inflammatory mechanism of Biota orientalis. METHODS Using rat leukocytes and rabbit platelets as experimental material the biosynthesis of leukotriene, 12-hydroxyheptadecatrienoic acid(12-HHT) and 12-hydroxyeicosatetraenoic acid(12-HETE) in the cells was determined with HPLC. RESULTS Biota orientalis was shown to inhibit the biosynthesis of leukotriene B4(LTB4) and 5-hydroxyeicosatetraenoic acid(5-HETE) with IC50 of 0.40 and 0.41 mg/ml crude herb, respectively. It was also displayed to inhibit biosynthesis of 12-HHT in the platelets. CONCLUSION Biota orientalis leaves contain anti-inflammatory components and the anti-inflammatory mechanism was related with inhibiting metabolism of arachidonic acid.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of China Pharmaceutical University
Año:
2001
Tipo del documento:
Artículo
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