Study on Dissolution of Amidarone Hydrochloride Tablets / 医药导报

ABSTRACT

To establish a method for the deter mination of dissolution of amiodarone hydrochloride tablets. Methods: Samples from five different factories were tested by the paddle meth od with the dissolving medium of 1% SLS. Results: The resu lts showed that there were very significant differences(P＜0.01) in dissolut ion parameters among the tested samples. Conclusion: It is necessary for testing the dissolution of the amiodarone product to control its quality and ensure clinical efficacy and safety.