T CELL IMMUNE RESPONSE TO THE CIRCUMSPOROZOITE PROTEINOF PLASMODIUM FALCIPARUM, SOUTHERN CHINA ISOLATE FCC/HN AND ANTIGEN-INDUCED HL-2 AND IFN-γ Production ANALYSIS OF SPECIFIC / 中国人兽共患病学报
Chinese Journal of Zoonoses
; (12): 32-34, 2000.
Article
en Zh
| WPRIM
| ID: wpr-434089
Biblioteca responsable:
WPRO
ABSTRACT
Inthis study, the DNA fragment encoding the regions Ⅰ to Ⅱ of CSP gene from Plasmodium falciparm isolate FCC1/HN was cloned into an. expression vector pcDNA3 contained cytomegalovius (CMV) and transformed into human Hela cell line. The expressed protein PfCSP (condidate vaccine) was used to immunize BALB/c mice by subcutaneous、 intravenous or intraperitoneal administration respectively. The splenocyte of BALB/c mice immumized with the condidate vaccine released significantly IL-2 and IFN-γ following stimulation with this vaccine. It is associated with increase of the splenic T lymphocyte proliferation stimulated by this vaccine and enhancement of NK cell killing activity in the former studies. These results suggested that the vaccine could stimulate T cell response and enhance the cell-mediated immunity.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Zoonoses
Año:
2000
Tipo del documento:
Article