Efficacy and safety of huperzine A combined with memantine in patients with Alzheimer disease / 中国医师进修杂志

ABSTRACT

Objective To observe the efficacy and safety of huperzine A combined with memantine in patients with Alzheimer disease (AD).Methods Sixty-five cases of AD were randomly divided into control group(32 cases) and treatment group(33 cases) by order of admission.The patients in control group were given memantine.The patients in treatment group were given huperzine A combined with memantine.The efficacy and safety was observed and compared between two groups.Results The mini-mental state examination score after treatment of 24 weeks in treatment group was higher than that in control group [(17.9 ± 1.8) scores vs.(16.2 ± 1.2) scores,P ＜ 0.05].The AD assessment scale of cognitive scale score after treatment of 24 weeks in treatment group was lower than that in control group [(19.9 + 4.8) scores vs.(22.2 ± 5.2) scores,P ＜ 0.05].The superoxide dismutase level after treatment of 24 weeks in treatment group was higher than that in control group [(102.4 ± 2.3) U/L vs.(95.4 ± 7.6) U/L,P ＜ 0.05].The neuron-specific enolase level after treatment of 24 weeks in treatment group was lower than that in control group [(6.3 ± 1.2)μ g/L vs.(7.4 + 1.4)μ g/L,P ＜ 0.05].During treatment,patients showed no serious adverse reactions.Conclusion Huperzine A and memantine has synergistic effects,the combined treatment in AD is safe and reliable.