Your browser doesn't support javascript.
loading
Relationship between the expression of SOCS-1/3 in the peripheral blood mononuclear cells and interferon therapeutic response in patients with chronic hepatitis B / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1921-1923, 2013.
Artículo en Chino | WPRIM | ID: wpr-434573
ABSTRACT
Objective To investigate the relationship between the the expression of SOCS-1/3 in the peripheral blood mononuclear cells (PBMCs) and interferon therapeutic response in patients with chronic hepatitis B.Methods 50 patients with chronic hepatitis B were given interferon therapy.After 24 weeks treatment,according to biochemical and virologic response,they were divided into two groupsresponse and non response group.HBV-DNA was detected by PCR.The SOCS-1/3 mRNA levels were measured by RT-PCR.Results The expression of SOCS-1 in the PBMCs of response group after 24 weeks treatment was significantly higher than that before interferon therapy (P < 0.05).The expression of SOCS-3 in the PBMCs of response group after 24 weeks trentment was significantly lower than that before interferon therapy (P < 0.05).In non response group,there were no significant differences in the expression of SOCS-1/3 (P > 0.05).Conclusion The increase expression of SOCS-1 mRNA and the decrease of SOCS-3 mRNA in the PBMCs in chronic hepatitis B patients received 24 weeks interferon-therapy probably is relevant to the IFN-α antiviral effect.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Primary Medicine and Pharmacy Año: 2013 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Primary Medicine and Pharmacy Año: 2013 Tipo del documento: Artículo