The effect of hydrochlorothiazide combined with captopril and simvastatin in the treatment of elderly hypertension patients with hyperlipidemia / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of hydrochlorothiazide combined with captopril and simvastatin in the treatment of elderly patients with hypertension and hyperlipidemia.Methods 50 elderly patients with hypertension and hyperlipidemia were randomly divided into two groups.The control group(25 cases) was given hydrochlorothiazide combined with captopril,the study group (25 cases) was given simvastatin on the basis of the control group.The blood pressure,changes in blood lipid levels and cerebrovascular events in 12 months were compared between the two groups.Results The blood pressure was declined in two groups,there was no significant difference (t =1.13,1.32,1.43,1.31,1.23,1.24,1.42,all P ＞ 0.05).After treatment,blood lipid levels of the study group significantly improved compared with before treatment (t =10.56,8.34,11.35,9.34,12.78,9.35,13.54,10.95,all P ＜ 0.05).The incidence rate of cerebrovascular events in 12 months of the study group was 12.0％,which was significantly lower than 28.0％ of the control group (x2 =8.45,P ＜ 0.05).Conclusion The elderly patients with hypertension and hyperlipidemia given antihypertensive and lipid lowering therapy can significantly reduce the incidence rate of long-term cardiovascular and cerebrovascular event,which is worth to be promoted in clinical.