Dehydropregnenolon acetat synthesized from 3 beta-acetoxy-pregn-5-en-17 beta-OL-20-YN

ABSTRACT

Researching synthetic method of Dehydropregnenolon acetat (DPA, 3β-acetoxy-pregn-5, 16-dien-20-on) from 3β- acetoxy-pregn-5-en 17β-ol-20-yn, a conclusion is given that using this method dicobalt hexacarbonyl was created in the first time in group acethylen, 3β- acetoxy-pregn-5-en 17β-ol-20-yn is synthesized with good output from equivalent 17β- hydroxy derivative. Respond not attach generates auxiliary products like known methods. Through two methods hydrating and hydrating in gentle conditions, dehydro pregnenolon acetat is synthesized with quite good output from 3β- acetoxy-pregn-5-en 17β-ol-20-yn. Intermediary compounds and final products characterized by melt point, infared spectrum, proton magnetic spectrum and weight spectrum