H-type hypertension in health check-up populations / 中华健康管理学杂志

ABSTRACT

Objective To explore clinical characteristics of H-type hypertension in health check-up populations so as to provide evidence for stroke prevention.Methods A total of 42 251 health check-up individuals (male 27 746,female 14 505,average age (46 ± 9) years) who visited our center during May,2009 and February,2012 were enrolled and responded to the investigation.In face to face interview,their age,gender,cigarette smoking and alcohol consumption were recorded.Height,body weight and blood pressures were measured.Serum lipid profiles,blood glucose,uric acid (UA),creatinine (Cr),homocysteine and urine albumin creatinine ratio (ACR) were tested.The subjects were then assigned to the H-type hypertension group,common hypertension group,high homocysteine group and control group.Analysis of Variance was used for data analysis.Results Of 42 251 participants,7748 were found to have H-type hypertension (18.34％ in whole subjects and 63.95％ in hypertensive subjects).Serum level of homocysteine and prevalence of common hypertension and H-type hypertension were significantly higher in males (P ＜ 0.05).Age and body mass index of the H-type hypertension group were significantly increased (P ＜ 0.05).The highest incidence of cigarette smoking and alcohol drinking was found in the homocysteine group (P ＜ 0.05),while the highest serum levels of Hb,UA,high sensitivity-C reactive protein (hs-CRP),and Cr occurred in the H-type hypertension group.Moreover,total cholesterol,triglycide,low-density lipoprotein cholesterol,and microalbumin/creatinine were not significantly different between the common hypertension group and the H-type hypertension group (P ＞ 0.05),although were significantly different between the controls and the H-type hypertensive patients (P ＜ 0.05).Conclusion The prevalence of Htype hypertension may be increased with the increasing serum levels of biological markers for nutritional metabolism.Higher level of homocysteine dose not seem to aggregate lipid disorders and early renal damage.