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Effect of a Dual Drug-Coated Stent With Abciximab and Alpha-Lipoic Acid in a Porcine Coronary Restenosis Model
Korean Circulation Journal ; : 241-247, 2011.
Artículo en Inglés | WPRIM | ID: wpr-43510
ABSTRACT
BACKGROUND AND

OBJECTIVES:

The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model. MATERIALS AND

METHODS:

A total of 10 pigs were randomized into two groups (10 pigs, 10 coronaries in each group) in which the coronary arteries were stented with a dual-coated stent and a bare metal stent (control) by randomization. Stents were deployed with oversizing (stent/artery ratio 1.3 1) in the porcine coronary arteries, and histopathology was assessed 28 days after stenting.

RESULTS:

There was no significant difference in the injury score between the two groups. In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120+/-85 cells vs. 159+/-80 cells, p=0.048). There was no significant difference in the fibrin score between the two groups (0.16+/-0.34 in the dual-coated stent group vs. 0.25+/-0.48 in the control stent group, p=0.446). The neointima area was not significantly different between both groups (1.55+/-0.8 mm2 in dual-coated stent group vs. 1.40+/-0.86 mm2 in the control stent group, p=0.447).

CONCLUSION:

Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Fragmentos Fab de Inmunoglobulinas / Fibrina / Inhibidores de Agregación Plaquetaria / Distribución Aleatoria / Stents / Ácido Tióctico / Vasos Coronarios / Reestenosis Coronaria / Stents Liberadores de Fármacos Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: Korean Circulation Journal Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Porcinos / Fragmentos Fab de Inmunoglobulinas / Fibrina / Inhibidores de Agregación Plaquetaria / Distribución Aleatoria / Stents / Ácido Tióctico / Vasos Coronarios / Reestenosis Coronaria / Stents Liberadores de Fármacos Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: Korean Circulation Journal Año: 2011 Tipo del documento: Artículo