Effects of glucocorticoid in patients with tuberculous pleuritis and its impact on the level of serum cancer antigen 125 / 中国医师进修杂志

ABSTRACT

Objective To investigate the effects of glucocorticoid in patients with tuberculous pleuritis and its impact on the level of serum cancer antigen 125 to provide theoretical basis for the treatment of tuberculous pleuritis.Methods One hundred and sixty patients with tuberculous pleuritis were divided into treatment group and control group with 80 cases each by random digits table method.The patients in two groups were given anti-TB medication,and the treatment group was given oral prednisone on the basis of anti-TB medication.The clinical efficacy and serum cancer antigen 125 level change was observed.Results Thirty-seven cases had excellent effect,35 cases showed good effect,and 8 cases was invalid in treatment group and there were 16,45 and 19 cases in control group respectively,and there was significant difference between two groups(P ＜ 0.05).The fever subsidence time,pleural effusion subsidence time,pleural effusion drawing volume,and thickening of pleura in treatment group was less than that in control group [(9.16 ±3.74) d vs.(15.54 ± 0.97) d,(11.78 ± 3.86) d vs.(16.78 ± 3.50) d,(2345.64 ± 321.75) ml vs.(3549.03 ±434.86) ml,40.00％(32/80) vs.80.00％(64/80)],and there was significant difference (P ＜ 0.05).There was no significant difference in serum cancer antigen 125 before treatment between two groups (P ＞ 0.05).The levels of serum cancer antigen 125 after treatment of 7,14 and 30 d in treatment group was lower than that in control group [(268.78 ± 93.86) μ g/L vs.(385.78 ± 143.43) μ g/L,(159.64 ± 31.96) μg/L vs.(255.03 ± 44.56) μg/L,(45.34 ± 12.94) μg/L vs.(167.75 ± 32.76) μ g/L],and there was significant difference (P ＜ 0.05).Conclusions The clinical efficacy of glucocorticoid in treatment of tuberculous pleuritis can improve the clinical symptoms early.It is worthy of clinical application.