Combination therapy of lamivudine and Yigan decoction in the treatment of patients with chronic hepatitis B / 中国基层医药

ABSTRACT

Objective To explore the clinical effect of combination therapy of Iamivudine and Yigan decoction in treatment of chronic hepatitis B.Methods 52 patients with chronic hepatitis B were selected and divided into control group and combination group randomly according to the digital table.Based on regular treatments,control group received treatment of lamivudine,and based on treatment of control group,combination group received treatment of Yigan decoction.Treatment efficacy,viral serological response rate,viral nucleic acid response rate and cellular immunity status were observed and compared.Results Compared with control group,treatment efficacy increased significantly from 73.08％ to 84.62％ (P ＜ 0.05) ; viral serological response rate and viral nucleic acid response rate increased significantly at the same time,from 23.08％ to 65.38％ and from 38.46％ to 88.46％ respectively (P ＜0.05) ;Composition of CD4+ T cells increased significantly in all patients after treatment,but more significantly in combination group (P ＜ 0.05) ; Composition of CD8+ T cells decreased significantly in combination group after treatment (P ＜0.05) ; ratio of CD4+/CD8+ increased significantly after treatment in all patients but more significantly in combination group (P ＜ 0.05).Conclusion Combination therapy of lamivudine and Yigan decoction is an ideal treatment of chronic hepatitis B,which can improv viral serological response,viral nucleic acid response and cellular immunity status,better than application of lamivudine alone.