The interaction between chemotherapy agents and transemetil in association with continuous arterial infusion / 中华肝胆外科杂志

ABSTRACT

Objective To explore the role of transemetil combined with various chemotherapy agents under the circumstance of continuous arterial infusion.Method MTT assays in cultured HepG2 and 7702 in vitro were used to detect the effects different sequences among different chemotherapy agents combined with transemetil.Results When combined with docetaxel,epirubicin,5-fluorouracil,pemetrexed disodium,cisplatin,or gemcitabine,transemetil had a synergistic effect.When combined with other agents,there was no synergistic or antagonistic effect.The synergistic effects were observed when transemetil acted during or after the use of chemotherapy agents.However,when chemotherapy agents were mixed with transemetil in advance,their effects decreased.Conclusion Transemetil showed an obvious synergistic effect when combined with certain chemotherapy agents.Different sequences between transemetil and chemotherapy agents showed different effects,and the mechanisms need further research to fully understand.