Effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 immunoreactivity and protein levels in the gerbil hippocampus after transient cerebral ischemia / 대한해부학회지
Anatomy & Cell Biology
;
: 54-63, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-43657
ABSTRACT
Stress has long been known to be a causative factor of various disease states. In this study, we investigated the effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 (PECAM-1), a very important mediator in inflammation, immunoreactivity and protein levels as well as neuronal damage, in the gerbil hippocampus after 5 minutes of transient cerebral ischemia. Transient ischemia-induced neuronal death was shown in CA1 pyramidal cells 4 days after ischemia/reperfusion. However, repeated restraint stress protected neuronal death induced by ischemic damage. In the ischemia-group, PECAM-1 immunoreactivity and its protein levels were significantly increased in all the hippocampal subregions 4 days after ischemia/reperfusion. However, PECAM-1 immunoreactivity and its protein levels did not change significantly in the hippocampus of the stress-ischemia-group compared to the sham-groups. These results indicate that repeated restraint stress protects neuronal damage induced by transient cerebral ischemia, and this may be associated with maintenance of PECAM-1levels.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plaquetas
/
Isquemia Encefálica
/
Ataque Isquémico Transitorio
/
Gerbillinae
/
Células Piramidales
/
Molécula-1 de Adhesión Celular Endotelial de Plaqueta
/
Hipocampo
/
Inflamación
/
Neuronas
Idioma:
Inglés
Revista:
Anatomy & Cell Biology
Año:
2010
Tipo del documento:
Artículo
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