Role of MHC class Ⅰ-related molecules A on NK cells immunotherapy in esophageal cancer patients after operation / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 365-370, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-436626
ABSTRACT
Objective To explore the relevance of expression of MHC class Ⅰ-related molecules A (MICA) molecule and NK cells immunotherapy in esophageal cancer patients after operation.To analyze the significance of MICA expression in NK cell immunotherapy.Methods 100 patients of esophageal cancer were divided into 3 group,surgical alone group,MICA negative with NK therapy group (MICA-group) and MICA positive with NK therapy group (MICA+ group).The immunity indicators and tumor markers including the levels of CD3+,CD4+ T cells,ratio of CD4+/CD8+, NK cells,Treg cells,the levels of Th1/Th2/Th17 cytokine,the antibody IgA,IgM,IgG and the tumor markers of CEA,SCC,CA199,CYFRA21-1 were detected before treatment and after treatment 60 days.Results The positives rates of CD3+,CD4+ T cells,NK cells and the ratio of CD4+/CD8+ in peripheral blood from MICA+ patients group were higher than those of before treatment [(68.3±7.6) % vs (56.2±4.1) %,(39.8±8.2) % vs (30.8±4.7) %,(22.2±4.7) % vs (18.7±5.5) %,(1.49±0.30) vs (1.15±0.61),P < 0.05],meanwhile the levels of Treg cells was lower than those of before treatment [(8.1± 4.0) % vs (13.4±4.5) %,P < 0.05].There was no statistical significant difference of positive rate of CD8+ T cells [(26.9±6.2) % vs (27.8±7.1) %,P > 0.05].The levels of Th1 cytokin (IL-2,IFN-γand TNF-α) increased and Th2 cytokin (IL-4,IL-6 and IL-10) decreased after treatment.The level of Th17 cytokine was not different significantly (P > 0.05).The content of IgA,IgM,IgG in MICA+ group were effectively improved after treatment.The tumor markers CEA,SCC,CA199,CYFRA21-1 had no statistically change before and after treatment.Conclusion The results indicate that NK cells immunotherapy can enhance the cellular immunity and humoral immunity of MICA positive esophageal cancer patients after operation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Cancer Research and Clinic
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS