Expression and significance of Wnt11 in kidney / 国际儿科学杂志

ABSTRACT

Wnt signaling pathways is a hot focus in recent years,which plays important regulatory roles in cell proliferation,differentiation and migration.Wnt signaling pathways include classical Wnt signaling pathways and non classical Wnt signaling pathways.Wnt11 is a very important signal molecule in the nonclassical WNT signaling pathways and kidney development,which plays a positive regulatory effect in the development of kidney and become silent in mature kidney.Studies have shown that Wnt11 re-express in the renal fibrosis.This paper discusses the function of the Wnt11 in kidney development and the relationship between Wnt11 and renal fibrosis.