The multi-drug resistance mechanism and treatment of multidrug-resistant acinetobacter baumannii / 国际儿科学杂志

ABSTRACT

While broad-spectrum antibiotics are widely used in these years,multidrug-resistant,extensively drug resistant,even pan drug resistant bacteria arise constantly.Acinetobacter baumannii is a common conditioned pathogen,and multidrug-resistant acinetobacter baumannii (MDRAB) has become one of the trickiest problems in nosocomial infection.The resistant mechanism of MDRAB include:producing antimicrobial inactivator,changing target site or cell function,adventitia barrier and effiux pump.Currently,sulbactam,carbapenem,polymyxin,tetracycline and some other antibiotics are used in MDRAB infection.Since lacking of extensive clinic study,there is no guideline up to now,the experience is especially less in pediatrics.