Progress of vitamin D, vitamin D receptor and rickets / 国际儿科学杂志

ABSTRACT

Vitamin D has a wide range of biological effects mediated through vitamin D receptor(VDR) in body,including regulating calcium-phosphorus metabolism,which has an important influence on normal bone formation and mineralization.Rickets is a common bone metabolic disease in children.Different types of rickets have different causes,but their pathophysiological processes,clinical manifestations and treatments are closely related with the influence of vitamin D and VDR on bone metabolism.