The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population / 中国癌症杂志
China Oncology
;
(12): 512-518, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-438410
ABSTRACT
Background and purpose:
The E-cadherin as a pivotal structural protein is important for cellular polarity and maintainance of normal tissue morphology and cellular differentiation. Recently some study investigated the impact of the C/A genetic polymorphism at-160 from the site of the E-cadherin gene promoter on susceptibility in NPC. To evaluate the association of the E-cadherin gene promoter-160 C/A single nucleotide polymorphism (SNP) and nasopharyngeal carcinoma risk in a Chinese population, we designed a hospital-based case-control study.Methods:
Subjects included in this study were 303 patients deifnitely diagnosed with NPC, and 318 matched healthy controls. We used TaqMan Probe method for analyzing polymorphism.Results:
The A/A genotype was associated with increased risk of NPC after being adjusted for age and gender (adjusted OR=2.09, 95%CI1.03-4.22, P=0.04). When 2 gender groups were analysed respectively, female group with A/A genotypes showed a higher risk (OR=7.57, 95%CI1.57-36.47, P=0.012). Besides, among NPC patients compared with males A/A genotype, females with A/A genotype had a signiifcant risk(OR=2.66, 95%CI1.14-6.20, P=0.024).Conclusion:
The A/A genotype of E-cadherin promoter-160 C/A might be genetic risk factor for NPC, especially female patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Idioma:
Chino
Revista:
China Oncology
Año:
2013
Tipo del documento:
Artículo
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